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. 2023 Jul 29;12(8):1064. doi: 10.3390/biology12081064

Figure 4.

Figure 4

Peripheral couplings are frequent in adult CASQ1-null fibers. (A,B) Peripheral couplings in WT muscle (at 1 week of age) and in CASQ1-null fibers (at 4 months of age). Arrows in panels (A,B) point to electron densities representing RyRs/feet. (C,D) Arrays of RyRs/feet forming multiple rows (arrows) in internal junctions. (E) Freeze fractures of the surface membrane showing DHPRs in peripheral couplings organized in tetrad arrays (see the insets for details). Bars: (A,B), 0.2 µm; (C,D), 0.1 µm; (E), 0.25 μm; gallery of images, 0.1 μm.