Table 2.
DEGs involved in PINK/Parkin mitophagy pathway.
| Gene | Fold Change CTRL vs. MPP+ |
q-Value CTRL vs. MPP+ |
Fold Change MPP+ vs. CBN 10 μM + MPP+ |
q-Value MPP+ vs. CBN 10 μM + MPP+ |
|---|---|---|---|---|
| AMBRA1 | 0.17 | 3.77 × 10−11 | −0.24 | 1.19 × 10−11 |
| CALCOCO2 | 1.21 | 0 | −0.11 | 1.11 × 10−3 |
| FIS1 | 0.09 | 1.08 × 10−3 | - | - |
| GABARAP | 1.40 | 1.57 × 10−40 | - | - |
| GABARAPL1 | 2.66 | 0 | - | - |
| GABARAPL2 | - | - | −0.23 | 1.81 × 10−6 |
| MAP1LC3A | 1.78 | 1.64 × 10−199 | - | - |
| MAP1LC3B | −0.24 | 5.69 × 10−10 | −0.44 | 1.45 × 10−14 |
| MAP1LC3B2 | - | - | −3.07 | 1.03 × 10−2 |
| MFN1 | 0.65 | 3.93 × 10−182 | 0.08 | 6.60 × 10−3 |
| MFN2 | −0.44 | 2.30 × 10−142 | - | - |
| NBR1 | 0.31 | 4.19 × 10−43 | - | - |
| OPTN | 2.41 | 0 | −0.29 | 1.71 × 10−45 |
| PINK1 | 0.70 | 2.08 × 10−65 | −0.18 | 1.07 × 10−3 |
| PRKN | 0.22 | 4.01 × 10−3 | - | - |
| RAB7A | - | - | −0.09 | 2.95 × 10−5 |
| RHOT1 | 0.80 | 7.11 × 10−304 | −0.13 | 3.69 × 10−6 |
| RHOT2 | 0.61 | 9.55 × 10−174 | - | - |
| RPS27A | 1.31 | 0 | −0.14 | 2.98 × 10−133 |
| SQSTM1 | 0.96 | 0 | −0.24 | 1.09 × 10−17 |
| TAX1BP1 | 0.30 | 5.27 × 10−90 | 0.07 | 4.80 × 10−4 |
| TBC1D15 | 0.60 | 2.71 × 10−148 | 0.12 | 2.95 × 10−5 |
| TBC1D17 | 0.71 | 8.08 × 10−112 | 0.08 | 3.98 × 10−2 |
| TBK1 | 0.10 | 2.15 × 10−2 | - | - |
| TOMM7 | 1.37 | 0 | −0.27 | 5.58 × 10−32 |
| UBA52 | 1.39 | 0 | −0.07 | 6.76 × 10−28 |
| UBB | 1.14 | 0 | −0.20 | 0 |
| UBC | 1.85 | 0 | −0.22 | 0 |
| USP15 | 0.64 | 9.36 × 10−109 | - | - |
| USP8 | 0.42 | 2.66 × 10−74 | 0.07 | 1.66 × 10−2 |
The 30 DEGs involved in PINK1/Parkin mitophagy with relative-fold change and q-value in CTRL vs. MPP+ and MPP+ vs. CBN 10 μM + MPP+. The column Fold Change shows for each DEG the difference in the level of expression computed by log2(MPP+/CTRL) or log2(CBN 10 μM + MPP+/MPP+). The q-Value column was obtained correcting the p-value through Benjamini–Hochberg correction. All values were rounded to the second decimal digit.