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Immunohistochemistry in primary cutaneous anaplastic large cell lymphoma. (A) CD30 is strongly and diffusely positive in the neoplastic cells with a membranous and paranuclear dot (Golgi) pattern. (B) CD3 is positive in some cases, whereas in others it may be negative or only weakly positive. (C) The tumor cells are usually positive for CD4 and for (D) cytotoxic markers, in this case TIA-1.
