Table 1.

Stimuli that induce NKG2D ligand expression in cancer.

Stimulus	Subtype/Notes	References
DNA-damaging agents	Radiation	[49,50,51]
	Mitomycin C	[50]
	Hydroxyurea	[50]
	5-Fluorouracil	[50,52]
	Cisplatin	[50]
	Temozolomide	[51]
	Doxorubicin	[53]
	Melphalan	[53]
	Etoposide	[53]
	Gemcitabine	[54]
	Docetaxel	[54]
	Vincristine	[55]
STING pathway		[56,57]
Cell cycle inhibition	Mediated via DNA damage response	[50]
DNA polymerase inhibitor		[50]
Oxidative stress		[58,59]
Heat shock		[32,36,49] but not [50]
Transcription factors	E2F	[60]
	KLF4	[61]
	ATF4	[62]
Oncogenic pathways	BCR/ABL	[63]
	c-myc	[64,65]
	Ras	[66]
	ErbB signalling	[67,68]
Cancer-associated metabolic alterations		[69,70]
Cancer-associated inflammation	See text