ETR |
erythematotelangiectatic rosacea |
PPR |
papulopustular rosacea |
PhR |
phymatous rosacea |
OR |
ocular rosacea |
TLRs |
Toll-like receptors |
KCs |
keratinocytes |
PAMPs |
pathogen-associated molecular patterns |
DAMPs |
damage-associated molecular patterns |
MCs |
mast cells |
NF-κB |
nuclear factor-kappa B |
TNF |
tumor necrosis factor |
IL |
interleukin |
AhR |
arylhydrocarbon receptor |
CCL |
chemokine (C-C motif) ligand |
KLK5 |
kallikrein 5 |
JAK |
janus kinase |
STAT |
signal transducer and activator of transcription |
mTORC1 |
mammalian target of rapamycin complex 1 |
MMP9 |
matrix metalloproteinase 9 |
NLRP3 |
NOD-like receptor family pyrin domain containing 3 |
PRRs |
pattern recognition receptors |
NPs |
neuropeptides |
MRGPRX2 |
Mas-related G protein-coupled receptor member X2 |
VEGF |
vascular endothelial growth factor |
NO |
nitric oxide |
ROS |
reactive oxygen species |
ADAMDEC1 |
ADAM-like Decysin-1 |
GBP5 |
guanylate-binding protein 5 |
NEAT1 |
nuclear paraspeckle assembly transcript 1 |
FPR1 |
formyl peptide receptor 1 |
EGFR |
epidermal growth factor receptors |
FGF |
fibroblast growth factor |
UV |
ultraviolet |
TRP |
transient receptor potential |
PACAP |
pituitary adenylate cyclase-activating polypeptide |
SP |
substance P |
VIP |
vasoactive intestinal peptide |
CGRP |
calcitonin gene-related peptide |
5-HT |
serotonin |
PAR2 |
protease-activated receptor 2 |
TEWL |
transepidermal water loss |
CLDNs |
claudins |
SIBO |
small intestinal bacterial overgrowth |
CXCL |
C-X-C motif chemokine ligand |
GPBAR1 |
G protein-coupled bile acid receptor 1 |
TSLP |
thymic stromal lymphopoietin |
GST |
glutathione S-transferase |
HLA |
human leukocyte antigen |
TACR3 |
tachykinin 3 receptor |
VDR |
vitamin D receptor |
ER |
endoplasmic reticulum |
S1P |
sphingosine-1-phosphate |
HPA |
hypothalamic-pituitary-adrenal |
FDA |
Food and Drug Administration |
IGA |
Investigator Global Assessment |
CEA |
Clinician Erythema Assessment |
PSA |
patient self-assessment |
IPL |
intense pulsed light |
Nd:YAG |
neodymium: yttrium–aluminum–garnet laser |
PDL |
pulsed dye laser |
KTP |
potassium titanyl phosphate laser |
PDT |
photodynamic therapy |
siRNA |
small RNA interference |