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. 2023 Jul 31;11(8):2153. doi: 10.3390/biomedicines11082153
ETR erythematotelangiectatic rosacea
PPR papulopustular rosacea
PhR phymatous rosacea
OR ocular rosacea
TLRs Toll-like receptors
KCs keratinocytes
PAMPs pathogen-associated molecular patterns
DAMPs damage-associated molecular patterns
MCs mast cells
NF-κB nuclear factor-kappa B
TNF tumor necrosis factor
IL interleukin
AhR arylhydrocarbon receptor
CCL chemokine (C-C motif) ligand
KLK5 kallikrein 5
JAK janus kinase
STAT signal transducer and activator of transcription
mTORC1 mammalian target of rapamycin complex 1
MMP9 matrix metalloproteinase 9
NLRP3 NOD-like receptor family pyrin domain containing 3
PRRs pattern recognition receptors
NPs neuropeptides
MRGPRX2 Mas-related G protein-coupled receptor member X2
VEGF vascular endothelial growth factor
NO nitric oxide
ROS reactive oxygen species
ADAMDEC1 ADAM-like Decysin-1
GBP5 guanylate-binding protein 5
NEAT1 nuclear paraspeckle assembly transcript 1
FPR1 formyl peptide receptor 1
EGFR epidermal growth factor receptors
FGF fibroblast growth factor
UV ultraviolet
TRP transient receptor potential
PACAP pituitary adenylate cyclase-activating polypeptide
SP substance P
VIP vasoactive intestinal peptide
CGRP calcitonin gene-related peptide
5-HT serotonin
PAR2 protease-activated receptor 2
TEWL transepidermal water loss
CLDNs claudins
SIBO small intestinal bacterial overgrowth
CXCL C-X-C motif chemokine ligand
GPBAR1 G protein-coupled bile acid receptor 1
TSLP thymic stromal lymphopoietin
GST glutathione S-transferase
HLA human leukocyte antigen
TACR3 tachykinin 3 receptor
VDR vitamin D receptor
ER endoplasmic reticulum
S1P sphingosine-1-phosphate
HPA hypothalamic-pituitary-adrenal
FDA Food and Drug Administration
IGA Investigator Global Assessment
CEA Clinician Erythema Assessment
PSA patient self-assessment
IPL intense pulsed light
Nd:YAG neodymium: yttrium–aluminum–garnet laser
PDL pulsed dye laser
KTP potassium titanyl phosphate laser
PDT photodynamic therapy
siRNA small RNA interference