Table 1.
Lipidomic signature from serum in PD.
| Demographics | Control (n = 51) | PD (n = 101) | p-Value |
|---|---|---|---|
| Gender (Female/Male) | 20/31 | 39/62 | 0.540 a |
| Age, years, mean (SD) | 65.28 ± 8.78 | 66.65 ± 8.86 | 0.413 b |
| Disease duration, years, mean (SD) | - | 3.0 (0.5, 10) | - |
| Education, Junior high school or less, (%) | 34 (66.67%) | 73 (72.28%) | 0.573 a |
| UPDRS total score, media (min, max) | - | 56 (16, 166) | - |
| H-Y stage, media (min, max) | - | 2 (1, 5) | - |
| MMSE score, mean (SD) | 27.78 ± 1.82 | 27.31 ± 1.93 | 0.147 b |
| MOCA score, mean (SD) | 28.41 ± 1.47 | 27.71 ± 1.46 | 0.006 b** |
| TG (mg/dL), mean (SD) | 109.20 ± 39.41 | 106.51 ± 33.51 | 0.663 c |
| TC (mg/dL), mean (SD) | 205.06 ± 31.78 | 204.46 ± 26.29 | 0.903 c |
| HDL (mg/dL), mean (SD) | 57.15 ± 10.83 | 58.32 ± 10.03 | 0.512 c |
| LDL (mg/dL), mean (SD) | 124.55 ± 28.52 | 122.66 ± 23.36 | 0.666 c |
a Chi-square test. b Unpaired t-test. c Mann-Whitney test. ** p < 0.01 versus control. Abbreviations: PD, Parkinson’s Disease; SD, standard deviation; H&Y stage, Hoehn–Yahr stage; UPDRS, Unified Parkinson’s Disease Rating Scale; MMS, mini-mental state examination; MOCA, Montreal cognitive assessment; TG, triglyceride; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein cholesterol.