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. 2023 Jul 28;13(8):1181. doi: 10.3390/biom13081181

Figure 5.

Figure 5

Effects of increasing doses of Ang II upon the proliferation of human cultured normal and cancerous kidney cells and the effects of losartan or CGP4221A. Normal and cancerous kidney cells were stimulated with increasing concentrations of Ang II (0, 0.1, 1, 10, and 100 nM) for 24 h in serum-deprived medium, or the cells were pretreated with 1 µM losartan or 1 mM CGP4221A for 45 min. Proliferation was analyzed by a spectrophotometric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenol-2H-tetrazolium bromide (MTT) assay. The data are means ± S.D. of five different experiments (n = 5). Values with shared letters are not significantly different according to Bonferroni–Dunn post hoc tests.