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Illustration of the genes responsible for the heavy chains (HCs) of HLA classes. In HLA class I, the HCs generated by genes in chromosome 6 combine with B2m generated from the gene at chromosome 15, whereas HLA class II is a result of dimerization of HCs formed from genes in chromosome 6. The illustration guides to hypothesize the generation of a new class of HLAs (a neo-HLA class) from genes in chromosome 6 by their homo- or hetero-dimerization.
