Table 1.

Intergroup comparison differences at both durations.

		Co Mean ± SD	ChN Mean ± SD	Sim Mean ± SD	ChSimN Mean ± SD
Osteoblasts	2 weeks	91.33 ± 10.9	146.85 ± 21.6	112.32 ± 22.5	98.28 ± 20.7
	4 weeks	48.92 ± 12.6	79.92 ± 33.2	65.51 ± 13.7	70.85 ± 34.5
	p value *	0.001	0.001	0.001	0.102
Osteocytes	2 weeks	53.35 ± 9.7	73.78 ± 30.5	70.14 ± 22.6	61.71 ± 13.0
	4 weeks	75.31 ± 14.0	106.42 ± 24.7	91.75 ± 28.3	80.85 ± 13.4
	p value *	0.001	0.048	0.14	0.019
Osteoclasts	2 weeks	1.0 ± 0.77	2.71 ± 1.1	1.42 ± 0.53	1.57 ± 0.78
	4 weeks	0.61 ± 0.49	1.14 ± 1.06	0.85 ± 0.89	1.0 ± 0.57
	p value *	0.066	0.02	0.18	0.15
Trabecular number	2 weeks	12.52 ± 3.9	14.57 ± 5.8	13.42 ± 4.9	17.71 ± 4.7
	4 weeks	4.23 ± 1.4	7.28 ± 1.9	6.57 ± 1.7	10.0 ± 7.2
	p value *	0.001	0.008	0.004	0.038
Trabecular area	2 weeks	0.87 ± 0.53	1.87 ± 0.93	1.53 ± 0.69	2.04 ± 0.81
	4 weeks	2.75 ± 0.62	3.66 ± 0.64	3.46 ± 1.9	3.87 ± 0.58
	p value *	0.001	0.002	0.038	0.001
Bone marrow area	2 weeks	1.26 ± 0.58	2.65 ± 1.0	1.84 ± 0.74	2.91 ± 0.6
	4 weeks	0.69 ± 0.29	0.34 ± 0.1	0.56 ± 0.27	0.4 ± 0.37
	p value *	0.001	0.001	0.003	0.001

Co: control, ChN: chitosan nanoparticles, ChSimN: chitosan simvastatin nanoparticles, Sim: simvasatin. * Significant difference at p < 0.05 using independent t-test.