Table 2.
The effect of pharmacological inhibition of TGF-β signalling on the response of NA HBF to the dcEF.
| NA HBF; 3 V/cm dcEF; n = 50 |
Speed of Cell Migration [μm/min] | Cell Displacement [μm] | Directionality (cos γ) [No Unit] |
Orientation Index [No Unit] |
|---|---|---|---|---|
| Inhibitor (Target Protein) |
Mean ± SEM | Mean ± SEM | Mean ± SEM | Mean ± SEM |
| w/o (Control) | 0.301 ± 0.020 | 75.796 ± 8.270 | −0.451 ± 0.061 | 0.731 ± 0.040 |
| SB431542 (TGFβR1) | 0.302 ± 0.025 | 50.990 ± 6.972 * | −0.024 ± 0.083 * | 0.404 ± 0.078 * |
| U0126 (MEK1/2) | 0.376 ± 0.033 | 76.163 ± 10.766 | −0.137 ± 0.068 * | 0.531 ± 0.072 |
| SB203580 (p38) | 0.357 ± 0.031 | 72.527 ± 8.941 | −0.047 ± 0.066 * | 0.356 ± 0.077 * |
| Y-27632 (ROCK) | 0.355 ± 0.030 | 113.532 ± 12.974 * | −0.208 ± 0.069 * | 0.492 ± 0.065 * |
* statistically significant value compared to that of the control (p < 0.05).