Figure 4.

Structure of 2019-nCoV S in the prefusion conformation. (A) Schematic of 2019-nCoV S primary structure coloured by domain. Domains that were excluded from the ectodomain expression construct or could not be visualised in the final map are coloured white. SS, signal sequence; S2′, S2′ protease cleavage site; FP, fusion peptide; HR1, heptad repeat 1; CH, central helix; CD, connector domain; HR2, heptad repeat 2; TM, transmembrane domain; CT, cytoplasmic tail. Arrows denote protease cleavage sites. (B) Side and top views of the prefusion structure of the 2019-nCoV S protein with a single RBD in the up conformation. The two RBD down protomers are shown as cryo-EM density in either white or gray and the RBD up protomer is shown in ribbons coloured corresponding to the schematic in (A). Reprinted from [26] Figure 1, Copyright (2022) with permission.