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. 2023 Aug 9;15(16):4035. doi: 10.3390/cancers15164035

Figure 2.

Figure 2

AMER2 is a direct target of EWS-FLI1. (A). CHIP-sequencing data demonstrate that AMER2 is a direct target of EWS-FLI1. In A673 and SK-N-MC cells, EWS-FLI1 binds to the promotor of AMER2 directly, and the H3K27ac level is lower after EWS-FLI1 knockdown. In MSC, transduction of EWS-FLI1 enhances the H3K27ac level in the promotor region of AMER2. (B). Knockdown of EWS-FLI1 downregulates AMER2 in EwS cell lines apart from the TC-71 cell line. (C). AMER2 expression is higher in EwS tissues than in normal tissues. (D). Potential mechanism of AMER2 in the metastasis of EwS. *, p < 0.01; **, p < 0.05; ***, p < 0.001; ****, p < 0.0001.