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Immuno-targeting therapy for EwS. (A). Direct downstream targets of EWS-FLI1, such as CHM1, STEAP1, and PAPPA, could serve as TCR-based immunotherapy. IL1RAP and STEPA1 are potential targets for CAR-T therapy. NY-ESO-1 is not a direct target of EWS-FLI1, but it is also a good target for TCR-T therapy. NKX2-2, NROB1, and PAX7 are reliable diagnostic markers of EwS. (B). Negatively correlated genes of LSD1 (p < 0.05) in EwS samples are mainly enriched in immune responses.
