Table 1.
Human Cyclophilins. The human genome encodes for 17 different genes annotated as CyPs. Based on GeneCards [21] and Uniprot [22] data, the table shows for each of them the chromosomal localization, the name(s) of the respective proteins, their lengths, and subcellular localizations.
| Gene | Chromosome | Protein Name(s) | Length (AA) | Subcellular Localization |
|---|---|---|---|---|
| ppia | 7p13 | CyPA | 165 | Cytoplasm, Nucleus, ECM |
| ppib | 15q22.31 | CyPB | 216 | ER Lumen |
| ppic | 5q23.2 | CyPC | 212 | Cytoplasm |
| ppid | 4q32.1 | CyP-40, CyPD | 370 | Cytoplasm, Nucleus |
| ppie | 1p34.2 | CyP-33, CyPE | 301 | Nucleus |
| ppif | 10q22.3 | CyPD, CyP3, CyP-M, CyPF | 207 | Mitochondrial Matrix |
| ppig | 2q31.1 | SRCyP, SCAF10 | 754 | Nucleus, Nuclear Speckles |
| ppih | 1p34.2 | CyP-20, CyPH, USA-CyP | 177 | Cytoplasm, Nuclear Speckles |
| ppil1 | 6p21.2 | CYPL1, hCyPX, CGI-124 | 166 | Nucleus |
| ppil2 | 22q11.21 | CyP-60, CyC4, UBOX7 | 520 | Nucleus |
| ppil3 | 2q33.1 | CyPJ | 161 | Nucleus |
| ppil4 | 6q25.1 | PPIL4, HDCME13P | 492 | Nucleus |
| ppil6 | 6q21 | PPIL6, RSPH12 | 311 | Cytoplasm |
| ppwd1 | 5q12.3 | PPWD1 | 646 | Nucleus |
| ranbp2 | 2q13 | RANBP2, NUP358 | 3224 | Nucleus |
| cwc27 | 5q12.3 | CWC27, SDCCAG10 | 472 | Nucleus |
| nktr | 3p22.1 | CyPNK, P104 | 1462 | Cell Membrane |