Numbering of CyPD. Due to the differences between the gene product of ppif, the mature CyPD, and the crystal structures of CyPD deposited in the PDB, the same residue can be numbered in at least three different ways. Here, we will mostly consider the numbering of the mature CyPD, i.e., without the mitochondrial targeting sequence (MTS). The corresponding numbering of residue i in the immature CyPD, i.e., with the MTS, will be i + 29, while in the crystal structure will be i-13. The crystal structure numbering of CyPD is the same as the numbering of CyPA.