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. 2023 Aug 16;15(16):4126. doi: 10.3390/cancers15164126

Figure 2.

Figure 2

Menin inhibition increases expression of LXR target genes in CRC cells. (A–F) HT-29 cells (A,B), HCT-15 cells (C,D), or HCT-116 cells (E,F) were treated with vehicle (DMSO) or 1 μM MI-2-2 for 96 h, and expression of ABCA1 and ABCG1 was analyzed using RT-qPCR relative to actin. (G,H) HT-29 cells were treated with empty vector (vehicle) or menin-directed sgRNA for 96 h, and expression of ABCA1 (G) and ABCG1 (H) was analyzed using RT-qPCR relative to actin. * p < 0.05. ** p < 0.01. *** p < 0.001. # p < 0.06.