Figure A6.

Correlation of the best response of DDR agents with the tATM H score in 11 PDX models. (a) AZD7648 monotherapy, (b,c) represents the correlation of the tATM H score with the best response following olaparib treatment at 100 mg/kg QD and 100mg/kg BID, respectively, (d) AZD7648 + olaparib, and (e) AZD7648 + AZD6738 represents the correlation of the tATM H score with the best response. For combinations, values of best responses represent the % TGI for AZD6738 at 12.5 mg/kg BID (7ON 7OFF) and olaparib at 100 mg/kg QD in combination with AZD7648 at 100 mg/kg QD. The best response was calculated as the maximum % tumour growth inhibition (TGI) following a minimum of 14 days of tumour growth for each respective model. Horizontal dotted lines indicate a best response of 50% TGI.