Table 1.

Study design.

Treatment Group	Comments
Vehicle control
AZD6738, 12.5 mg/kg PO BID (14 days on, 14 days off)	BID dosed 8 h apart
AZD6738, 25 mg/kg PO BID (14 days on, 14 days off)	BID dosed 8 h apart
AZD7648, 100 mg/kg PO QD continuous
Olaparib, 100 mg/kg PO QD continuous
Olaparib, mono 100 mg/kg PO BID
AZD7648, 100 mg/kg PO QD continuous
AZD6738, 12.5 mg/kg PO BID (14 days on, 14 days off) + olaparib 100 mg/kg PO QD continuous	AZD6738 dosed 1 h after olaparib dose
AZD6738, 12.5 mg/kg PO BID (14 days on, 14 days off) + AZD7648, 100 mg/kg PO QD	AZD6738 dosed 1 h after AZD7648 dose
AZD7648, 100 mg/kg PO QD + olaparib, 100 mg/kg PO QD	Olaparib dosed 1 h after AZD7648 dose