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. 2023 Aug 10;45(8):6618–6633. doi: 10.3390/cimb45080418

Figure 2.

Figure 2

Chromosomal aberrations scored as breaks per metaphase in different cohorts. The entire cohort consisted of 37 female patients with pathogenic mutations in BRCA1 and 27 patients with pathogenic mutations in BRCA2, 121 female and 90 male healthy individuals, 101 female and 278 male patients with rectal cancer, and 147 female patients with breast cancer (the latter ones all with unknown BRCA1 mutation status). (A) Background aberrations for breaks per metaphase and (B) chromosomal radiation sensitivity scored as breaks per metaphase after ex vivo irradiation with 2 Gy ionizing radiation and background correction. (C) B/M values in the non-oncologic and oncologic BRCA1 group. (D) B/M values in the non-oncologic and oncologic BRCA2 group. Brackets indicate significant levels of differences between two groups. Horizontal lines depict 0.05 (A), and 0.5 and 0.55 (B) B/M cut-off values. B/M = Breaks per metaphase. Error bars indicate the mean value and the standard deviation.