Table 1.
Characteristics of patients with BRCA1/2 pathologic variants.
|
BRCA1/2 n = 64 (%) |
BRCA1 n = 37 (%) |
BRCA2 n = 27 (%) |
|||
|---|---|---|---|---|---|
| Mean age (range, years) | 45.7 (25–70) | 45.1 (26–68) | 46.6 (25–70) | ||
| Mean height (m) | 1.65 | 1.66 | 1.65 | ||
| Mean weight (kg) | 70.7 | 71.9 | 69.3 | ||
| Mean BMI (kg/m2) | 25.7 | 26.0 | 25.3 | ||
| Premenopausal | 32 (50.0) | 19 (51.4) | 13 (48.1) | ||
| Postmenopausal | 30 (46.9) | 16 (43.2) | 14 (40.7) | ||
| Not known | 2 (3.1) | 2 (5.4) | 0 | ||
| No breast cancer | 21 (32.8) | 9 (24.3) | 12 (44.4) | ||
| Breast cancer | 38 (59.4) | 26 (70.3) | 12 (44.4) | ||
| Breast cancer status not known | 5 (7.8) | 2 (5.4) | 3 (11.1) | ||
| Tumor stage | Tis | 2 (3.1) | 2 (7.7) | 0 | |
| T1 | 19 (29.7) | 9 (34.6) | 10 (83.3) | ||
| T2 | 12 (18.8) | 10 (38.5) | 2 (16.7) | ||
| T3 | 2 (3.1) | 2 (7.7) | 0 | ||
| T4 | 0 | 0 | 0 | ||
| Not known | 3 (4.7) | 3 (11.5) | 0 | ||
| Regional lymph nodes | N0 | 26 (40.6) | 16 (61.5) | 10 (83.3) | |
| N+ | 9 (14.1) | 7 (27) | 2 (16.7) | ||
| Not known | 3 (4.7) | 3 (11.5) | 0 | ||
| Distant metastasis |
M0 | 33 (51.6) | 21 (80.8) | 12 (100) | |
| M1 | 0 | 0 | 0 | ||
| Mx | 5 (7.8) | 5 (19.2) | 0 | ||
| Receptors | ER or PR positive | 10 (15.6) | 8 (30.8) | 2 (16.7) | |
| Triple negative | 19 (29.7) | 11 (42.3) | 8 (66.7) | ||
| HER2/neu positive | 7 (10.9) | 5 (19.2) | 2 (16.7) | ||
| Not known | 2 (3.1) | 2 (7.7) | 0 | ||
| Grading | G1 | 1 (1.6) | 1 (3.8) | 0 | |
| G2 | 6 (9.4) | 4 (15.4) | 2 (16.7) | ||
| G3 | 27 (42.2) | 17 (65.4) | 10 (83.3) | ||
| Not known | 4 (6.3) | 4 (15.4) | 0 | ||
| Mean B/M values | 0.47 | 0.46 | 0.48 | ||
B/M = Breaks per metaphase; Tis = Tumor in situ.