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. 2023 Aug 10;12(16):2034. doi: 10.3390/cells12162034

Figure 1.

Figure 1

(a) Indices of endotoxemia (EndoCab, LBP, FABP) and systemic inflammation (IL-6, IP10) are elevated during HCV infection. Plasma levels of endotoxemia (EndoCab, LBP, FABP) and inflammation (IL-6, IP10, sCD163, sCD14) were measured by ELISA. Squares represent HCV-infected participants; closed circles represent uninfected controls <50 years old, and open circles represent uninfected controls >65 years old. Between groups, comparisons were made using Mann–Whitney U tests. p values ≤ 0.05 are considered statistically significant. Only statistically significant differences are shown. (b) Plasma IP10 declines after initiation of direct-acting anti-viral therapy. Plasma levels of endotoxemia (EndoCab, LBP, FABP) and inflammation (IL-6, IP10, sCD163, sCD14) were measured by ELISA pre-DAA therapy and at 4, 12, 24, and 48 after initiation of DAA therapy. Comparison between week 0 and each time point was measured by Wilcoxon matched-pairs signed rank test. Only statistically significant differences are shown.