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. 2023 Aug 19;12(16):2105. doi: 10.3390/cells12162105

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Secretion of functional factors by MSCs grown in media 1, 4, 7, 10, and 13. MSCs were grown in media 1 (100% αMEM+8%PL; black), 4 (95% αMEM+8%PL + 5% StemMACS^TM; blue), 7 (50% αMEM+8%PL + 50% StemMACS^TM; green), 10 (5% αMEM+8%PL + 95% StemMACS^TM; red) and 13 (100% StemMACS^TM; violet). The secretion of factors angiopoietin-2, PTH, PlGF, fractalkine, leptin, TNFβ, HB-EGF, FGF-23, FGF-2, sCD40L, endoglin, PDGF-AA, insulin, follistatin, OC, OPN, RANTES, MCP-3, M-CSF, VEGF-C, GROα, TSG-6, SOST, VEGF-A, IL-8, IL-6, HGF, TGFβ, DKK1, MCP-1, OPG and TSP-1 was analyzed for the period between media exchange and harvesting of cells and normalized to 1 × 10⁶ MSC/24 h. *: p < 0.05.