Table 2.
Recent studies featuring the use of ozone in dentistry.
| Authors and Publication Date | Study Title | Journal | Sample Size | Conclusion | Reference |
|---|---|---|---|---|---|
| Isler et al., 2018 | Effects of laser photobiomodulation and ozone therapy on palatal epithelial wound healing and patient morbidity | Photomed. Laser. Surg. | 36 patients | Significantly improves the healing of palatal lesions | [105] |
| Al-Omiri et al., 2018 | Randomized clinical trial on the comparison of bleaching outcomes using either ozone or hydrogen peroxide | Quintessence. Int. | 32 participants | Teeth containing similar bleaching outcomes | [106] |
| Durmus et al., 2019 | Effectiveness of the ozone application in two-visit indirect pulp therapy of permanent molars with deep carious lesion: a randomized clinical trial | Clin. Oral. Investig. | 105 lower first molar teeth |
Significant effect in reducing microorganisms |
[107] |
| Uraz et al., 2019 | Ozone application as adjunctive therapy in chronic periodontitis: clinical, microbiological and biochemical aspects | J. Dent. Sci. | 18 periodontitis patients |
Ozone therapy had no further benefits in terms of clinical, microbiological, or biochemical markers | [108] |
| Matys et al., 2020 | Effect of ozone and diode laser (635 nm) in reducing orthodontic pain in the maxillary arch: a randomized clinical controlled trial | Lasers. Med. Sci. | 76 patients | Diode lasers had a significant pain-relieving effect while ozone did not relieve pain | [109] |
| Grocholewicz et al., 2020 | Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial | Sci. Rep. | 92 participants | A combination of nano-hydroxyapatite gel and ozone therapy produced the best effect in remineralizing enamel | [110] |
| Al-Omiri et al., 2021 | Treatment of symptomatic, deep, almost cariously exposed lesions using ozone | Sci. Rep. | 84 participants | Ozone applied to partially excised cavities prior to repair alleviates pain | [111] |
| M. Serag Eldien and Fathy Hassabou, 2022 | Clinical and cytological assessment of platelet-rich fibrin versus topical ozonated oil in palatal wound healing after free gingival graft harvesting: randomized controlled trial | J. Oral. Maxillofac. Surg. Med. Patho. | 39 patients | It has a significant improvement in wound healing re-epithelialization | [112] |