Table 1.
Key surgical clinical trials.
| Study | Published | Study Arms | Endpoints | Outcomes |
|---|---|---|---|---|
| NSABP B-06 Fisher et al. [4] |
NEJM 1995 | Lumpectomy followed by XRT vs. lumpectomy vs. mastectomy |
DFS OS |
No difference |
| NSABP B-04 Fisher et al. [5] |
NEJM 2002 | Mastectomy followed by radiation in node-negative patients vs. mastectomy + ALND | DFS RFS DDFR OS |
No difference |
| ACOSOG Z0011 Giuliano et al. [6,7] |
Ann of surg 2010 JAMA 2011 |
ALND vs. no ALND in SLN-positive patients | locoregional recurrences OS | No difference |
| AMAROS Donker et al. [8] |
Lancet Oncology 2014 | Axillary surgery vs. radiation in patients with positive SLN | DFS OS |
Similar |
ALND: axillary lymph node dissection, DFS: disease free survival, RFS: recurrence free survival, DDFR: distant disease-free survival, OS: overall survival.