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Proposed schematics of the NLRP3 inflammasome activation in infected macrophages. The diagram shows the ability of Mycobacterium bovis and its culture filtrate extract (CFPE) to activate the NLRP3 inflammasome, probably through pattern-recognition receptors. The assembly of the inflammasome leads to the maturation of IL-1β, which damages the cell membrane, resulting in necrotic cell death. This figure was created using the Servier Medical Art Commons Attribution 3.0 Unported Licence).
