Table 1.

Summary of the cytotoxicity, most effective doses, and fold changes of COX-2 and IL-6 after single and combined doses of psilocybin, 4-AcO-DMT, ketanserin, capsaicin, curcumin, and eugenol in HSEIC.

Compounds	Short-Term Cytotoxicity	Long-Term Cytotoxicity	Most Effective Dose	Fold Change of COX-2	Fold Change of IL-6
Psi	N/A	N/A	40 μM	−3.8×	N/A
4-AcO-DMT	N/A	N/A	20 μM	−1.5×	N/A
Ket	≥40 μM	≥5 μM	1 μM	−1.7×	N/A
Cap	≥50 μM	≥0.5 μM	0.5 μM	−1.6×	N/A
Cur	≥5 μM	≥1 μM	0.5 μM	−3.8×	N/A
Eug	≥10 μM	≥10 μM	50 μM	−3.8×	N/A
Psi + Cap	N/A	10 μM Psi, ≥0.5 μM Cap	20 μM Psi, 0.5 μM Cap	−3.8×	−1.7×
Psi + Cur	10 μM Psi & 1 μM Cur	10/20 μM Psi, ≥0.5 μM Cur	40 μM Psi, 0.5 μM Cur	−28×	−1.6×
Psi + Eug	N/A	N/A	40 μM Psi, 25 μM Eug	−19×	−10×
4-AcO-DMT + Cap	N/A	N/A	20 μM 4-AcO-DMT, 0.5 μM Cap	−1.1×	−3.3×
4-AcO-DMT + Cur	N/A	10 μM 4-AcO-DMT, ≥0.5 μM Cur	40 μM 4-AcO-DMT, 0.5 μM Cur	−1.3×	−1.3×
4-AcO-DMT + Eug	N/A	N/A	40 μM 4-AcO-DMT, 25 μM Eug	−1.6×	−1.5×
Ket + Cap	N/A	N/A	5 μM Ket, 0.5 μM Cap	−2.1×	−2.0×
Ket + Cur	N/A	10 μM Ket, ≥0.5 μM Cur	1 μM Ket, 0.5 μM Cur	−3.5×	−1.1×
Ket + Eug	N/A	≥1 μM Ket, 25 μM Eug	10 μM Ket, 25 μM Eug	−2.8×	−3.0×

4-AcO-DMT, 4-acetoxy-N,N-dimethyltryptamine; Cap, capsaicin; Cur, curcumin; Eug, eugenol; Ket, ketanserin; Psi, psilocybin.