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. 2023 Aug 8;12(16):2019. doi: 10.3390/cells12162019
Drug/Treatment MOA Status Conditions
Aduhelm (aducanumab) A monoclonal antibody that targets beta-amyloid plaques in the brain Approved in June 2021 Mild cognitive impairment due to AD or mild AD
Gantenerumab A monoclonal antibody that targets beta-amyloid plaques in the brain. Phase III clinical trials Mild AD
Donanemab A monoclonal antibody that targets a modified form of beta-amyloid called N3pG Phase III clinical trials Early AD
Tauvid Imaging (flortaucipir F18) A diagnostic imaging agent that targets tau protein Approved on May 2020 Detection of tau pathology in the brain
Leqembi (Lecanemab) Remove sticky clumps of the toxic protein amyloid-β from the brain. Approved on 6 January 2023 Alzheimer’s disease