Table 6.

Antidepressant metabolic changes.

Ranking	Medication	Metabolic Change	Effect on the Patient
Antidepressants Tricyclics	Amitriptyline	Increased appetite by 19% [13]. Constipation 10% [14]. Weight gain of 10% [15]. Cardiovascular side effects 14% to 17% [14].	13.3% of patients with depression or anxiety who receive treatment with these psychotropic drugs for a period longer than 5 months’ notice significant changes in metabolism [13,15,16,17].
	Imipramine	Sedative effects [16]. Constipation 12%. Decreased blood pressure, dizziness 7% [14]. Metabolic risk 12% due to inappropriate drug metabolism [17].
	Clomipramine	Nausea, vomiting, intestinal flora alliteration and 12% to 17% body weight gain [18].
Antidepressants (SSRIS)	Fluoxetine	Weight gain (6.8% Cardiac disturbance (12.5) [19]. Pulmonary hypertension in the fetus during gestation (1st to 20%) [20].	5.5% 21 to 25.5% of patients who are on selective serotonin reuptake inhibitors have a sedentary lifestyle and non-compliance with diets, which has as a consequence relevant change in their metabolism [20,21]. 38.4% (95% CI: 31.1–45.7) of patients on medication for more than six months report side effects [22]. Effects such as insomnia or hypersomnia due to citalopram consumption decrease in the second week, as long as the consumption of the drug is adequate to the medical order [21].
	Sertraline	Weight gain (7%), 0.8% constipation [22]. Gastrointestinal disorders 0.65% [23]. Metabolic disorders and nutritional alteration 0.45% [24].
	Citalopram	4.6% Risk of postpartum hemorrhage [24].
	Escitalopram	0.79% glycemic alteration in diabetics [24]. 1.7% risk of metabolic disturbance in patients with coronary heart disease [19]. 1 to 10% risk of metabolic disorders [25]. 16.9% to 22.9% risk of gastrointestinal disturbance [26].
	Paroxetine	20–25% of digestive disorders [27]. 10–15% dry mouth and constipation [27,28].