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. 2023 Aug 12;13(8):1505–1520. doi: 10.3390/ejihpe13080110

Table 7.

Metabolic Changes observed in Anticonvulsants.

Ranking Medication Metabolic Change Effect on the Patient
Anticonvulsant Valproic acid 12.89% Constipation [11,12].
23.4% Weight gain [11,12].
Appetite and sleep changes [11].
100% of patients with diabetes, and hypertension, should not receive treatment with Fosphenytoin.
Fosphenytoin 79% BMI alteration.
56% increase in abdominal obesity [11,28].