Table 6.
AUC values of the plasma lipids with an AUC > 0.8 for each pair of groups compared.
| NASH vs. Control Comparison | Cut-Offs | |||||
|---|---|---|---|---|---|---|
| Lipids | AUROC (95% CI) | p Value | Cut-Off Point | AUROC (95% CI) | Sensitivity | Specificity |
| FA 12:0 | 0.92 (0.80–1) | <0.001 ** | 73.3 | 0.90 (0.79–1) | 0.800 | 1 |
| FA 14:0 | 0.87 (0.72–0.97) | <0.001 ** | 152 | 0.79 (0.63–0.93) | 0.667 | 0.917 |
| FA 20:1 | 0.83 (0.67–0.96) | <0.001 ** | 9.72 | 0.77 (0.60–0.93) | 0.867 | 0.667 |
| FA 18:3 n3 | 0.83 (0.66–0.97) | <0.001 ** | 66.1 | 0.79 (0.64–0.92) | 0.667 | 0.917 |
| Elongation index | 0.81 (0.63–0.96) | 0.132 | 0.324 | 0.75 (0.61–0.88) | 1 | 0.500 |
| FA 16:1 | 0.81 (0.61–0.96) | <0.001 ** | 145 | 0.82 (0.67–0.96) | 0.800 | 0.833 |
| NASH vs. NAFL Comparison | Cut-Offs | |||||
| Lipids | AUROC (95% CI) | p Value | Cut-Off Point | AUROC (95% CI) | Sensitivity | Specificity |
| Δ5-desaturase index | 0.85 (0.66–1) | <0.001 ** | 3.08 | 0.82 (0.64–0.96) | 0.900 | 0.750 |
| FA 18:3 n3 | 0.85 (0.67–1) | <0.001 ** | 66.1 | 0.86 (0.66–1) | 0.800 | 0.917 |
| FA 14:0 | 0.82 (0.59–0.96) | <0.001 ** | 152 | 0.76 (0.55–0.94) | 0.600 | 0.917 |
| FA 17:0 | 0.81 (0.61–0.94) | <0.001 ** | 26.5 | 0.76 (0.59–0.93) | 0.600 | 0.917 |
| PUFA | 0.80 (0.57–0.97) | <0.001 ** | 2.52 | 0.77 (0.58–0.95) | 0.700 | 0.833 |
| EFA | 0.80 (0.57–0.96) | <0.001 ** | 1.503 | 0.81 (0.62–0.96) | 0.700 | 0.917 |
| FA 18:2 | 0.80 (0.57–0.96) | 0.074 | 1.382 | 0.81 (0.65–0.96) | 0.700 | 0.917 |
The table contains (for the selected lipids and for each pair of groups compared): (a) The AUC values (95% CI) as well as the corresponding p value. (b) A defined cut-off point for each lipid, which is a threshold below from which the samples are classified in one category and above from this to the other. For these specific cut-offs, the AUC values (95% CI), as well as the sensitivity and specificity values, were recalculated. **: p value < 0.01, statistically significant.