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TRIM14 overexpression activated STAT3/HIF-1α expression in HCC tissues and cells. (A) Western blot revealed the profile of STAT3/HIF-1α in HCC cells where TRIM14 was overexpressed or knocked down. (B) STAT3/HIF-1α expression in the tumor tissues was verified with Western blot. (C) Immunohistochemistry confirmed HIF-1α and p-STAT3 expression. Scale bar = 100 μm. N = 3. ** p < 0.01 and *** p < 0.001 (vs. the vector or sh-NC group).
