Figure 1.

Graphic representation of the pro-inflammatory TSLP mediated complex and its intracellular signalling pathways (adapted after [1,13,14,15,16]). TSLP with an atypical open helical bundle core, wedges between TSLPR and IL-7Rα to mediate the T-shaped extracellular assembly. The brown star indicates site I (TSLP:TSLPR interface) with pronounced electrostatic complementarity, the blue star denotes site II (TSLP:IL-7Rα interface) and the orange one site III (IL-7Rα:TSLPR interface). TSLP, represented here in green, is the long-form TSLP (the common part with the short-form TSLP is presented in light green). The hidden red star highlights the binding region of tezepelumab overlapped by the binding region on TSLP on TSLPR. The parts noted 1, 2, and 3 of this figure represent complex molecular events at the receptor (1), transcription factors (2) and target genes (3) levels, as explained in the text.