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Cyclic guanosine monophosphate (cGMP) signaling in cardiomyocytes. cGMP signaling is initiated by two pathways: NO-sGC and NPRs. cGMP activates PKG, which subsequently phosphorylates various signaling molecules such as RGS2/4 and titin. cGMP also modulates cAMP and cGMP degradation. cGMP-bound PDE2 increases cAMP-hydrolyzing activity. cGMP competitively binds to PDE3, thereby inhibiting its activity. cGMP enhances cAMP action through PDE3 inhibition.
