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Involvement of cGMP signaling in the cardioprotective mechanism of sodium-glucose co-transporter-2 (SGLT2) inhibitors. Although the contribution of cGMP signaling to cardiac protection has not been established, it is feasible that cGMP signaling contributes to SGLT2 inhibitor-induced cardiac protection. Apoptosis is in part responsible for the protection of the heart. However, there is almost no report on the involvement of cGMP signaling in the inhibition of apoptosis.
