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. 2023 Aug 16;24(16):12866. doi: 10.3390/ijms241612866

Table 5.

Classification of sodium-glucose cotransporters (SGLTs).

Classification Isoform Physiological Functions
SGLTs SGLT1
SGLT2
SGLT3
SGLT4
SGLT5
SGLT6 (SMIT2 *)
SMIT1 *
  • ▪

    Myocardium expresses SGLT1 and SMIT1 (glucose taken up by SGLT1 and SMIT1 is used for ROS production but not for ATP production).

  • ▪

    SGLT2 inhibitors are effective against HF.

  • ▪

    SMIT is involved in the transport of myoinositol but not glucose.

* SMIT: sodium myo-inositol cotransporter.