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. 1977 Oct;53(5):292–294. doi: 10.1136/sti.53.5.292

Nitroblue tetrazolium test in experimental syphilis.

V Wicher, S Blakowski, K Wicher
PMCID: PMC1045424  PMID: 589423

Abstract

The reduction of nitroblue tetrazolium (NBT) by phagocytic leucocytes in peripheral blood has been examined in rabbits injected intratesticularly with Treponema pallidum, T. pallidum-free supernatant of orchitic testes, or normal rabbit testes supernatant. A significant (P less than 0.01) increase in NBT reduction was observed only in the infected animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baehner R. L., Nathan D. G. Quantitative nitroblue tetrazolium test in chronic granulomatous disease. N Engl J Med. 1968 May 2;278(18):971–976. doi: 10.1056/NEJM196805022781801. [DOI] [PubMed] [Google Scholar]
  2. FRAZIER C. N., BENSEL A., KEUPER C. S. Further observations on the duration of spirochetemia in rabbits with asymptomatic syphilis. Am J Syph Gonorrhea Vener Dis. 1952 Mar;36(2):167–173. [PubMed] [Google Scholar]
  3. Feigin R. D., Shackelford P. G., Choi S. C., Flake K. K., Franklin F. A., Jr, Eisenberg C. S. Nitroblue tetrazolium dye test as an aid in the differential diagnosis of febrile disorders. J Pediatr. 1971 Feb;78(2):230–237. doi: 10.1016/s0022-3476(71)80005-7. [DOI] [PubMed] [Google Scholar]
  4. Fitzgerald T. J., Miller J. N., Sykes J. A. Treponema pallidum (Nichols strain) in tissue cultures: cellular attachment, entry, and survival. Infect Immun. 1975 May;11(5):1133–1140. doi: 10.1128/iai.11.5.1133-1140.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Goldstein I. M., Feit F., Weissmann G. Enhancement of nitroblue tetrazolium dye reduction by leukocytes exposed to a component of complement in the absence of phagocytosis. J Immunol. 1975 Jan;114(1 Pt 2):516–518. [PubMed] [Google Scholar]
  6. Gordon A. M., Rowan R. M., Brown T., Carson H. G. Routine application of the nitroblue tetrazolium test in the clinical laboratory. J Clin Pathol. 1973 Jan;26(1):52–56. doi: 10.1136/jcp.26.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Graves S. R., Johnson R. C. Effect of pretreatment with Mycobacterium bovis (strain BCG) and immune syphilitic serum on rabbit resistance to Treponema pallidum. Infect Immun. 1975 Nov;12(5):1029–1036. doi: 10.1128/iai.12.5.1029-1036.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Matula G., Paterson P. Y. Spontaneous in vitro reduction of nitroblue tetrazolium by neutrophils of adult patients with bacterial infection. N Engl J Med. 1971 Aug 5;285(6):311–317. doi: 10.1056/NEJM197108052850603. [DOI] [PubMed] [Google Scholar]
  9. Park B. H., Fikrig S. M., Smithwick E. M. Infection and nitroblue-tetrazolium reduction by neutrophils. A diagnostic acid. Lancet. 1968 Sep 7;2(7567):532–534. doi: 10.1016/s0140-6736(68)92406-9. [DOI] [PubMed] [Google Scholar]
  10. Schell R. F., Musher D. M. Detection of nonspecific resistance to Listeria monocytogenes in rabbits infected with Treponema pallidum. Infect Immun. 1974 Apr;9(4):658–662. doi: 10.1128/iai.9.4.658-662.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Schell R., Musher D., Jacobson K., Schwethelm P., Simmons C. Effect macrophage activation on infection with Treponema pallidum. Infect Immun. 1975 Sep;12(3):505–511. doi: 10.1128/iai.12.3.505-511.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]

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