Figure 8.

Adezmapimod suppressed the development of mechanical allodynia induced by ddC in both male and female BALB/c mice. (A) Withdrawal threshold to mechanical stimuli of male mice before (baseline) and on day 7 post-ddC (25 mg/kg) administration and treatment with adezmapimod (30 mg/kg). (B) Withdrawal threshold to mechanical stimuli of female mice before (baseline) and on day 7 post-ddC (25 mg/kg) administration and treatment with adezmapimod (30 mg/kg). Each bar represents the median and interquartile range obtained from six to seven mice. ** p < 0.01 compared to baseline values for ddC-treated mice (Mann–Whitney U test). ### p < 0.001 compared to mice treated with ddC plus vehicle on day 7 (two-way repeated measures ANOVA followed by Tukey’s multiple comparisons test).