Table 1.

Application of Polymer-Based Stimuli-Responsive Hydrogels in Disease Treatment.

Polymer Sources	Responsive Property	Synthetic Method	Applications	References
N-isopropylacrylamide with acrylic acid	pH/temperature response	Free-radical polymerization	Wound repair	[89]
Sodium alginate	ROS response	Phenyl boronic ester bonds		[90]
Oxidized dextran and ε-polylysine	pH/ROS response	Schiff base linkages and boronic ester bonds		[91]
Pluronic F127	Light response	Hydrophobic-hydrophilic interactions		[92]
Poly(N-isopropyl acrylamide) and alginate	Light/ magnetic response	Covalently crosslinked and ionically crosslinked		[93]
Hyaluronic acid	ROS response	Michael addition reaction	Myocardial infarction treatment	[94]
Carboxymethyl cellulose and Poly vinyl alcohol	pH/ROS response	Phenyl boronic ester bonds		[95]
Chitosan	ROS response	Boronate ester groups		[96]
Gelatin	Electric response	EDC/NHS crosslinking		[97,98]
Poly(carboxybetaine methacrylate)	Electric response	Michael addition reaction		[99]
Poly(ethylene glycol)	Enzyme response	Michael addition reaction		[100]
Poly (propylene sulfide)120	ROS response	Van der Waals forces	Traumatic brain injury treatment	[101]
4-sulfobenzoic acid attached peptide	Enzyme response	Self-assembly		[102]
Chitosan, hydroxyethyl cellulose, hyaluronic acid	Temperature response	Physical interaction		[103]
Hyaluronic acid and poly vinyl alcohol	Glucose/ROS response	Phenyl boronic ester bonds		[104]
Polyethyleneglycol-polycaprolactone-N1-(4-boronobenzyl)-N3-(4-boronobenzyl)-N1,N1,N3,N3-tetramethylpropane-1,3-diaminium	ROS response	Phenyl boronic ester bonds	Articular cartilage repair and regeneration	[105]
Chitosan	Temperature/pH response	Schiff base linkages and Physical interaction		[106]
Chitosan and chondroitin sulfate	Ultrasound responsive	Schiff base linkages		[107]
Chitosan and silk fibroin	Temperature response	Physical interaction		[108]