Table 2.
Clinically approved hydrogel products, grouped by their material class and broad indication.
| Product | Company/Sponsor Institution | Main Constituent | Indication | Status |
|---|---|---|---|---|
| Artefill | Suneva Medical, Inc. | Polymethylmethacrylate beads, collagen, and lidocaine | Facial wrinkles and folds | Clinically approved |
| EUFLEXXA | Ferring Pharmaceuticals Inc. | Hyaluronic acid | Knee osteoarthritis | Clinically approved |
| INFUSE bone graft | Medtronic Sofamor Danek USA, Inc. | Collagen and recombinant human bone morphogenetic protein-2 | Spine, oral-maxillofacial, and orthopedic trauma | Clinically approved |
| Algisyl-LVR Hydrogel Implant | LoneStar Heart, Inc. | Alginate | Heart failure | Clinically approved |
| Lgisite M Condress | Smith & Nephew | Alginate collagen | Wound | Clinically approved |
| Comfeel Plus Contour Dressing | Coloplast Corp | Carboxymethylcellulose | Wound | Clinically approved |
| Argiform | Research Centre BIOFORM | Polyacrylamide and silver ions | Knee osteoarthritis | Clinical trial |
| VentriGel | Ventrix, Inc. | Native myocardial extracellular matrix | Myocardial infarction | Clinical trial |
| BiolineRX | BioLineRx Ltd. | Alginate | Myocardial infarction | Clinical trial |
| Radiesse | Bioform Medical, Inc. | Hydroxylapatite, carboxymethylcellulose | signs of facial fat loss and volume loss | Clinical trial |
| Elevess | Anika Therapeutics | Hyaluronic acid, lidocaine | Moderate to severe facial wrinkles and folds | Clinical trial |