Figure 4.

Genome-wide cell-specific DNA methylation profile. (a) Total number of cell type-specific DMPs (csDMPs) and breakdown by hyper- and hypomethylated. (b) Plot representing genome-wide effect size for all csDMPs, by cell type. Each dot represents a significant csDMP. The Y-axis represents the model estimate for effect size and the X-axis represents genome coordinates; chromosomes are in chronological order and represented by alternating color. The highlighted region represents the MHC class II regions (c) MHC class II region cell-specific DNA methylation. Shown is the effect size in each immune cell type for the index CpG of the nine major DMRs identified in whole blood. Values are estimates extracted from our cell-specific models. Blue/negative values represent negative estimates or hypomethylation at those CpGs, while red/positives values represent positive estimates or hypermethylation. A darker color indicates a higher effect size.