Table 1.

The advantages and disadvantages of platelet-rich fibrin.

Advantages of Platelet-Rich Fibrin	References
Preparation and application are easy and efficient	[46,47,48]
Natural biomaterial, obtained by autologous blood sample. No risk of infection, immune rejection, or a reaction	[5,47]
Does not require bovine thrombin and anticoagulants	[24,49]
Fibrin’s three-dimensional architecture with growth factors is better suited for tissue regeneration	[50]
It can increase the healing rate	[51,52]
Decreased patient bleeding, discomfort, and pain after surgery	[47]
Disadvantages of Platelet-Rich Fibrin
Autologous blood means the final amount is limited	[53]
Short handling time and fast degradation	[40]