Table 3.
Current evidence of clinical applications of PRP and PRF.
| Indication or Procedure | PRP | PRF |
|---|---|---|
| Achilles tendinopathy | PRP is not superior to placebo treatment [105] | |
| Acute muscle injuries | Abundance of high-quality evidence [106] | |
| Aging skin | Temporarily induce modest improvement in facial skin appearance, texture, and lines [107] | |
| Alopecia areata | Abundance of high-quality evidence [108] | Leukocyte PRF is superior to control treatment [109] |
| Androgenic alopecia | PRP is likely to reduce hair loss, increase hair diameter and density [110] | |
| Arthrogenous temporomandibular disorders | PRP is more effective than conservative treatments [111] | |
| Carpal tunnel syndrome | PRP represents a promising therapy for patients with mild to moderate CTS [112] | |
| Diabetic ulcers | PRP may improve ulcer healing [113] | |
| Elbow tendinopathy | PRP injections improved pain and function more effectively than corticosteroid injections at the long-term follow-up [114] PRP significantly improved pain and elbow function in the intermediate term (12–26 weeks) [115] |
|
| Greater trochanteric pain syndrome | PRP is not superior to placebo treatment [116] A single PRP injection is superior to a single corticosteroid injection [117] |
|
| Knee osteoarthritis | PRP injections have a low risk of harm and beneficial ≥12 month outcomes [118] | |
| Mandibular third molar surgery | Decrease in prevalence of alveolar osteitis [119] | |
| Maxillary sinus augmentation | Improves the healing period and bone formation [120] | |
| Medication-related osteonecrosis of the jaw | Abundance of high-quality evidence [121] | Abundance of high-quality evidence [121] |
| Patellar tendinopathy | Multiple injections of PRP obtained positive outcome [122] Pain relieving and functional improvement [123] |
|
| Plantar fasciopathy | PRP may provide a long-term effect in relieving pain [124] | |
| Ridge preservation procedure | L-PRF reduced the magnitude of vertical and horizontal bone resorption [125] | |
| Rotator cuff tears | PRP treatment decreases the retear rate and improves the clinical outcomes [104] PRP improves patient outcomes [103] |
L-PRF yields no beneficial effect in clinical outcome [126] PRF has no benefit in improving patient outcomes [103] |