HWH	Holothurian wall hydrolysate
CTX	Cyclophosphamide
LH	Levamisole hydrochloride
TJs	Tight junction proteins
qRT-PCR	Quantitative real-time
IL-6	Interleukin-6
TNF-α	Tumor necrosis factor-α
ZO-1	Zonula occluden-1
IEC	Intestine epithelial cells
Th1	T helper cell 1
Treg	Regulatory T cell
TLR4	Toll-like receptor 4
MAPKs	Mitogen-activated protein kinases
PI3K	Phosphoinositide 3-kinase
AKT (PKB)	Protein kinase B
FOXO3a	Forkhead box protein O3a
RT	Retention time
NC	Normal control
H&E	Hematoxylin-Eosin
PAS	Periodic Acid-Schiff
OTUs	Operational taxonomic units
ACE	Abundance-based Coverage Estimator
PCA	Principal component analysis
PCoA	Principal coordinate analysis
LDA	Linear discriminant analysis
LEfSe	Linear discriminant analysis effect size
SCFA	Short chain fatty acids
IBDs	Inflammatory bowel diseases
HFD	High-fat diet
CE	Collision energy
HCD	Higher energy Collision-induced Dissociation
LC-MS/MS	Liquid chromatography-tandem mass spectrometry
MW	Molecular weight
PTM	Post-translational modification
PC	Positive control
PMSF	Phenylmethylsulfonyl fluoride
BCA	Bicinchoninicacid
SDS-PAGE	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis
PVDF	Polyvinylidene fluoride
HRP	Horseradish peroxidase
ECL	Enhanced chemiluminescence
GAPDH	Glyceraldehyde-3-phosphate dehydrogenase
AGC	Automatic gain control