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. 2023 Aug 11;24(16):12673. doi: 10.3390/ijms241612673

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Sensitivity of the inward current recorded in the U251 edge cells to 1 mM nickel extracellular perfusion. (a) Experimental traces elicited by depolarizing the voltage steps of +10 mV from the holding potential of −60 mV to +140 mV (protocol shown at the bottom) in the control conditions (left traces) and after the local perfusion of 1 mM nickel (central traces). Digital subtraction shows the nickel-sensitive current (right traces). Inset: The PN leak subtraction method (see the Section 4) does not significantly alter the I–V plot of the inward current. (b) Mean I–V relationships before (black dots) and after (gray rhombuses) the local perfusion of nickel (n = 5 cells). (c) Average inward current activation time to peaks measured at different test potentials.