Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 19;24(16):12979. doi: 10.3390/ijms241612979

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

SPM suppresses the expression of poly(I:C)/TNFα-induced cytokines in HaCaT cells. (a) Schematic experimental design of 24 h poly(I:C)/TNFα pro-inflammatory cocktail stimulus accompanied by SPM or Mometasone (positive control). (b) IL-1β, IL-6, IL-33, and TSLP mRNA levels after 24 h poly(I:C)/TNFα stimulation and co-treatment with SPM or Mometasone. N = 6 biological replicates. Error bars represent the mean ± SD. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001, as determined via One-way ANOVA followed by Tukey’s multiple comparison test. Ctr; control, P(I:C)/TNFα; poly(I:C)/TNFα + vehicle(water), P(I:C)/TNFa + S; poly(I:C)/TNFα + 20% SPM, P(I:C)/TNFα + M; poly(I:C)/TNFα + 1 μM Mometasone.