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. 2023 Aug 19;24(16):12979. doi: 10.3390/ijms241612979

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The topical agent containing SPM alleviates mild chronic atopic dermatitis and eczema symptoms. (a) Investigator global assessment (IGA), (b) photographic assessment (PA) scores (from 1 to 5), (c) dermatological quality of life index (DLQI) scores (from 0 to 30), (d) visual analog scale (VAS) scores (from 1 to 10) for pruritus (itch) of skin lesions treated with SPM containing topical agent (SPM) and the same topical agent without SPM (vehicle) between day 0 and day 21. Subjects reporting no pruritus at the beginning of the study were excluded from the analysis (N = 14). (a–d) ANCOVA with Mann–Whitney U-test, * p < 0.05, n = 20 unless noted otherwise.