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. 2023 Aug 19;24(16):12979. doi: 10.3390/ijms241612979

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Corneum stratum and lymphocyte infiltration at the dermis–epidermis interface in skin lesions of one subject before and after topical application of SPM. (a) Histopathological examination of treated skin as assessed by hematoxylin-eosin (H & E) staining. Lymphocyte infiltration (pockets of nuclei, black arrows) at the dermis-epidermis interface. 200× objective. Scale bar is 100 μm. (b) Stratum corneum thickness before and after 3 weeks of SPM treatment. (c) Counts of lymphocytes infiltrating the epidermis–dermis interface before and after 3 weeks of SPM treatment.