Figure 5.

LY3154207 binding is associated with a tightening and loosening of the extracellular and intracellular regions of the receptor, respectively. (A) An overview of the D1R coupled with Gs protein and in complex with both dopamine and LY3154207 (PDB 7LJD). The extracellular and intracellular subsegments of the D1R are colored in white, while the middle segments are in gray (see Section 3 for their definitions). Our PIA analysis shows that the majority of extracellular subsegments have a tendency to move closer together (B), while the majority of intracellular subsegments have greater COM–COM distances (C) in the D1R/dopamine-LY3154207 compared to the D1R/dopamine-alone condition.