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. 2023 Aug 21;18:4751–4778. doi: 10.2147/IJN.S417422

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© 2023 Zou et al.

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Strategies for the development of exosome-based multifunctional nano-delivery platforms. The multifunctional nano-delivery platforms mainly include active loading of therapeutic agents, targeted functional modifications, evasion of MPS clearance (CD47-SIRPα axis, PEG membrane coating); controlled release using sensitive chemical bonds or hybridized liposomes (PH-sensitive, light-sensitive, heat-sensitive), inorganic nanoparticles (heat-sensitive, light-sensitive) and in vivo bioimaging; utilization of adjuvant therapies, such as magnetothermal therapy, photothermal therapy to further improve the efficacy.