Table 2.
Clinical trials combining curcumin and standard drugs.
| NCT Number | Study Title | Drug in Combination to Curcumin | Curcumin Used | Condition | Status | Phase | References |
|---|---|---|---|---|---|---|---|
| NCT02439385 | Avastin/FOLFIRI in Combination with Curcumin in Colorectal Cancer Patients With Unresectable Metastasis | FOLFIRI: Folinic acid, 5-FU and Irinotecan | Ginsenoside-modified nanostructured lipid carrier containing Curcumin. Curcumin Sigma-Aldrich | Colorectal Cancer | Completed | Phase 2 | [108] |
| NCT03192059 | Study of Pembrolizumab, Radiation and Immune Modulatory Cocktail in Cervical/Uterine Cancer | Cyclophosphamide, Aaspirin, Lansoprazole, Vitamin D, Pembrolizumab, Radiotherapy | Curcumin, CurcuPhyt | Cervical Cancer, Endometrial Cancer, Uterine Cancer | Completed | Phase 2 | [109,110] |
| NCT00192842 | Gemcitabine with Curcumin for Pancreatic Cancer | Gemcitabine | Curcumin C3—complex, SabinsaCorporation (Piscataway NJ) | Pancreatic Cancer | Completed | Phase 2 | [111] |
| NCT01490996 | Combining Curcumin with FOLFOX Chemotherapy in Patients with Inoperable Colorectal Cancer | FOLFOX: Folinic acid, 5-FU and oxaliplatin | Curcumin C3—complex, SabinsaCorporation (Piscataway NJ) | Colon cancer metastasis | Completed | Phase 1–2 | [96,112,113] |
| NCT01859858 | Effect of Curcumin on Dose Limiting Toxicity and Pharmacokinetics of Irinotecan in Patients with Solid Tumors | Irinotecan | Curcumin phosphatidylcholine complex, Meriva | Advanced colorectal cancer | Completed | Phase 1 | [110] |
| NCT00852332 | Docetaxel with or without a Phytochemical in Treating Patients With Breast Cancer | Docetaxel | Curcumin capsules | Breast Cancer | Terminated | Phase 2 | |
| NCT02095717 | Multicenter Study Comparing Taxotere Plus Curcumin Versus Taxotere Plus Placebo Combination in First-line Treatment of Prostate Cancer Metastatic Castration Resistant (CURTAXEL) | Taxotere | Curcumin formulated in 500 mg capsules | Prostate Cancer Metastatic Castration Resistant | Terminated | Phase 2 | |
| NCT01608139 | Study of Curcumin, Vorinostat, and Sorafenib | Vorinostat (SAHA), and Sorafenib | Curcumin powder | Advanced cancers | Withdrawn | Phase 1 | |
| NCT01048983 | Reducing Symptom Burden—Non Small Cell Lung Cancer (NSCLC) | Armodafinil, Bupropion, and Minocycline | Curcumin stick pack | Non-Small Cell Lung Cancer | Withdrawn | Phase 1–2 | |
| NCT02321293 | A Open-label Prospective Cohort Trial of Curcumin Plus Tyrosine Kinase Inhibitors (TKI) for EGFR-Mutant Advanced NSCLC | Gefitinib and Erlotinib | CurcuVIVA™ | Lung cancer | Unknown status | Phase 1 | |
| NCT00295035 | Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients with Metastatic Colon Cancer | CELECOXIB | Curcumin | Colon cancer | Unknown status | Phase 3 | |
| NCT02724202 | Curcumin in Combination with 5FU for Colon Cancer | 5-flurorouracil | Curcumin BCM-95 | Metastatic colon cancer | Unknown status | Early Phase 1 | |
| NCT00486460 | Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients with Advance or Inoperable Pancreatic Cancer | Gemcitabine and Celebrex | Curcumin | Pancreatic Cancer | Unknown status | Phase 3 |